Saline Infusion Sonohysterogram (SIS)

A saline infusion sonohysterogram—also called a saline ultrasound—is a safe, minimally invasive imaging procedure used to evaluate the inside of the uterus. By combining ultrasound with a gentle infusion of sterile saline, this test provides a clearer, more detailed view of the uterine cavity than a standard pelvic ultrasound alone.

At Veritas Fertility & Surgery, we perform SIS in the comfort of our office to help identify conditions that may be affecting fertility or causing abnormal bleeding—quickly, efficiently, and with minimal discomfort.

ultrasound room

What is a Saline Infusion Sonohysterogram?

An SIS is an ultrasound exam in which sterile saline is introduced into the uterine cavity through a small, soft catheter. The saline gently expands the cavity, creating contrast that allows the ultrasound to detect even small changes in the uterine lining, such as:

  • Uterine isthmocele (cesarean scar defect)
  • Uterine polyps
  • Fibroids that distort the cavity
  • Adhesions (scar tissue)
  • Congenital uterine anomalies (e.g., septum)

Because the procedure is performed with ultrasound (not X-ray), there’s no radiation exposure.

How the Procedure Works

  1. A thin, flexible catheter is placed through the cervix into the uterus.
  2. Sterile saline is slowly infused while a transvaginal ultrasound is performed.
  3. As the saline outlines the uterine cavity, the contour of the uterine cavity can be carefully evaluated to identify any abnormalities in real time.

The procedure typically takes less than 10 minutes.

Benefits of SIS

  • Highly accurate detection of uterine abnormalities that may be missed on standard ultrasound
  • Quick and convenient—performed in our office, no hospital visit required
  • Minimally invasive—no anesthesia or sedation needed
  • Immediate results—findings are reviewed with you during the same visit

FAQs

A standard pelvic ultrasound looks at the uterus, ovaries, and pelvis, but sometimes small abnormalities inside the uterine cavity can be missed. An SIS uses sterile saline to gently expand the cavity, providing a clearer, more detailed view of the inside of the uterus—making it easier to detect issues like polyps, fibroids, scar tissue, or a uterine septum.

Most patients experience only mild cramping during the procedure. The discomfort usually lasts just a few minutes. Taking an over-the-counter anti-inflammatory like ibuprofen 1-2 hours before your appointment can help make you more comfortable.

Yes. In fact, SIS is often part of a fertility evaluation. We simply schedule it for the first half of your cycle—after your period ends but before ovulation—to ensure there’s no chance of interfering with an early pregnancy.

No. Most patients go right back to their normal activities the same day. You may notice light spotting for a day or two, which is normal.

WHAT OUR PATIENTS SAY

“Dr. Puthoff is amazing! He is compassionate, patient, and very intelligent. He seems to really care, and it feels like you’re in good hands. It is reassuring that he is so good at what he does and still allows you to make your own choices.”

“I am very blessed that the Lord brought Dr. Puthoff and his team into my life. His work and the treatment I received made it possible for us to have another child. That is a priceless joy and we couldn’t say thank you enough to Dr. Puthoff.”

“The friendly and welcoming attitude of Dr. Puthoff put me right at ease. He thoroughly explained the procedure and answered all of my questions. I felt extremely confident that he is the right surgeon for my procedure.”

“My husband and I were very pleased with how approachable and comforting Dr. Puthoff was. He took time to listen and to care. We never felt rushed. He gave us hope. That’s what we needed. Thank you Dr. Puthoff for what you do. Your job truly has a lasting impression and gift on your patients.”

“Because of my first visit and the attentive phone calls I have received since, I am confident I am in caring hands for my upcoming surgery. I feel extremely grateful to be getting such amazing care.”

“I always feel involved in my care. Dr. Puthoff has an excellent bedside manner and demonstrates a high level of professionalism.”

Ready to take the first step?

We’re here to help you achieve better reproductive health and fertility through restorative, compassionate treatments tailored just for you.